Rheumatology Medical News about risk of rheumatoid arthritis;androgen levels;hormone related genes

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

A prospective study of androgen levels, hormone related genes and risk of rheumatoid arthritis
Arthritis Research & Therapy, 06/29/09

Karlson EW et al. – Study demonstrates that the steroid hormone levels measured at a single time point prior to rheumatoid arthritis (RA) onset were not associated with RA risk. These findings do not suggest that androgens or the androgen receptor (AR), estrogen receptor 2 (ESR2), aromatase (CYP19) and progesterone receptor (PGR) genes are important to RA risk in women.

Methods

Aim was to determine the associations between plasma steroid hormones measured prior to RA onset and polymorphisms in the AR, ESR2, CYP19 and PGR and RA risk
AR, ESR2, CYP19, PGR SNPs were genotyped and the AR CAG repeat in RA case-control studies nested within the Nurses' Health Study (NHS), NHS II and the Women's Health Study
All controls were matched on cohort, age, Caucasian race, menopausal status, and postmenopausal hormone use
Plasma dehydroepiandrosterone-sulfate (DHEAS), testosterone, and sex hormone binding globulin (SHBG) were measured in 132 pre-RA samples and 396 matched controls in NHS cohorts

Results

Mean age of RA diagnosis was 55 yrs in both cohorts; 58% of cases were RF positive at diagnosis
No association between plasma DHEAS, total testosterone, or calculated free testosterone and risk of future RA
No association between individual variants or haplotypes in any of the genes and RA or seropositive RA
No association for the AR CAG repeat

<< Previous
Usefulness of erythrocyte-bound C4d as a biomarker to predict...

Next >>
Immunopathogenesis of spondyloarthritis: Which cells drive...