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A prospective study of androgen levels, hormone related genes and risk of rheumatoid arthritis
Arthritis Research & Therapy, 06/29/09
Karlson EW et al. – Study demonstrates that the steroid hormone levels measured at a single time point prior to rheumatoid arthritis (RA) onset were not associated with RA risk. These findings do not suggest that androgens or the androgen receptor (AR), estrogen receptor 2 (ESR2), aromatase (CYP19) and progesterone receptor (PGR) genes are important to RA risk in women.
Methods- Aim was to determine the associations between plasma steroid hormones measured prior to RA onset and polymorphisms in the AR, ESR2, CYP19 and PGR and RA risk
- AR, ESR2, CYP19, PGR SNPs were genotyped and the AR CAG repeat in RA case-control studies nested within the Nurses' Health Study (NHS), NHS II and the Women's Health Study
- All controls were matched on cohort, age, Caucasian race, menopausal status, and postmenopausal hormone use
- Plasma dehydroepiandrosterone-sulfate (DHEAS), testosterone, and sex hormone binding globulin (SHBG) were measured in 132 pre-RA samples and 396 matched controls in NHS cohorts
- Mean age of RA diagnosis was 55 yrs in both cohorts; 58% of cases were RF positive at diagnosis
- No association between plasma DHEAS, total testosterone, or calculated free testosterone and risk of future RA
- No association between individual variants or haplotypes in any of the genes and RA or seropositive RA
- No association for the AR CAG repeat
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Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
Arthritis Research & Therapy, 10/16/09
The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study
Arthritis & Rheumatism, 11/04/09
Erythrocyte sedimentation rate, CRP level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
Arthritis Care and Research , 11/02/09
Today in Rheumatoid Arthritis...keeping you current
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Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
Arthritis Care and Research , 11/03/09
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor [alpha] therapies: Does the risk change with the time since start of treatment?
Arthritis & Rheumatism, 11/05/09
Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? A 15-year follow-up
Scandinavian Journal of Rheumatology , 09/28/09
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