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Comparison of quantitative imaging of cartilage for osteoarthritis
Magnetic Resonance Imaging , 06/26/09
Taylor C et al. – Findings suggest that T1ρ, T2 and contrast-enhanced techniques may provide complementary information about the molecular environment in cartilage during the evolution of osteoarthritis (OA).
Methods- Study highlights the differences between various approaches to assess biochemical markers of cartilage integrity in degenerative joint diseases such as OA
- A comparison of MRI (T1, T2 and T1ρ) and contrast-enhanced CT in human articular cartilage, in presence and absence of gadolinium (Gd)-based contrast agent was carried out
- Pre- and postcontrast T2 values were similar on a regional level and correlated with each other
- T1 values were shortened on both a global and a spatial basis in the presence of Gd
- Similar results were found for T1ρ
- T2 values correlated mildly with postcontrast T1, T1(Gd) and with precontrast T1ρ values
- In addition, contrast-enhanced CT values correlated with both precontrast T1ρ and T1(Gd) more strongly than with precontrast T2
- Finally, T1(Gd) and precontrast T1ρ were moderately correlated with CT data
- However, T1(Gd) and precontrast T1ρ were completely uncorrelated
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