Your Article Summary
See Latest ArticlesDegradome expression profiling in human articular cartilage
Arthritis Research & Therapy, 06/25/09
Swingler TE et al. – This study provides a complete quantitative analysis of protease gene expression in cartilage; gives direction to future research on the specific function(s) of individual proteases or protease families in cartilage and may help to refine anti-proteolytic strategies in osteoarthritis (OA).
Methods- Expression profile of protease genes in all catalytic classes in normal human cartilage and from OA pts
- Human cartilage obtained from femoral heads at joint replacement for either OA or following fracture to the neck of femur (NOF)
- Total RNA was purified, and expression of genes assayed using Taqman(R) low density array qRT-PCR
- 538 protease genes were profiled, of which 431 were expressed in cartilage
- 179 genes were differentially expressed in OA vs NOF cartilage: 8 aspartic proteases, 44 cysteine proteases, 76 metalloproteases, 46 serine proteases and 5 threonine proteases
- Wilcoxon ranking as well as the LogitBoost-NR machine learning approach were used to assign significance to each gene, with the most highly ranked genes broadly similar using each method
Related Articles
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of interleukin-1beta-induced nuclear factor-kappaB-mediated inflammation and apoptosis
Arthritis Research & Therapy, 11/11/09
Relevance Score: 80%
Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes
Open Access Rheumatology: Research and Reviews, 11/03/09
Relevance Score: 78%
Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
Modern Rheumatology, 10/05/09
Relevance Score: 69%
Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using Magnetic Resonance Imaging
BMC Musculoskeletal Disorders, 11/06/09
Relevance Score: 68%
MR Imaging of the Articular Cartilage of the Knee
Seminars in Musculoskeletal Radiology, 11/06/09
Relevance Score: 67%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Anti-agalactosyl IgG antibodies in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis
Clinical Rheumatology, 12/04/09
Increased mRNA expression of collagen V gene in pulmonary fibrosis of systemic sclerosis
European Journal of Clinical Investigation, 12/04/09
The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome
Rheumatology, 12/01/09
Today in Osteoarthritis...keeping you current
Receive free subspecialty "5-minute updates" via email
ALO-01 (Morphine Sulfate and Naltrexone Hydrochloride) Extended-Release Capsules in the Treatment of Chronic Pain of Osteoarthritis of the Hip or Knee: Pharmacokinetics, Efficacy, and Safety
The Journal of Pain, 12/03/09
Can patellar tape reduce the patellar malalignment and pain associated with patellofemoral osteoarthritis
Arthritis Care and Research , 12/02/09
Ambulatory visit utilization in a national, population-based sample of adults with osteoarthritis
Arthritis Care and Research , 12/02/09