Rheumatology

Your Article Summary

See Latest Articles

Treatment thresholds for osteoporosis in men on androgen deprivation therapy: T-score versus FRAX?
Osteoporosis International, 06/24/09

Adler RA et al. – Study demonstrates that dual-energy X-ray absorptiometry (DXA) and new fracture prediction algorithm (FRAX™) tool with corrected femoral neck T-score identify different men on androgen deprivation therapy (ADT) for treatment of osteoporosis.

• Study determines if the new fracture prediction method, FRAX™, which is based on femoral neck DXA plus risk factors could determine which men should receive osteoporosis therapy
• Of 115 men undergoing ADT referred for DXA testing, those with BMD in spine, hip, or forearm of ≥2.5 standard deviations were considered treatment candidates
• Using FRAX™ with and w/o femoral neck BMD, men were treatment candidates if the 10-yr hip fracture risk was ≥3% or the major osteoporotic fracture risk was ≥20%

• Men averaged 77 yrs old; 58% were African–American, and 14.8% were current smokers
• Mean femoral neck T-score was -1.4
• Using DXA, 38 (33%) men would need treatment
• When FRAX™ was calculated including the femoral neck T-score, only 20 men met criteria for treatment
• However, when FRAX™ was calculated without the T-score, 62 men met criteria for treatment
• Overlap among the groups was surprisingly modest

Today in Bone Metabolism...keeping you current

Receive free subspecialty "5-minute updates" via email

Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09

Cardiovascular diseases and risk of hip fracture
JAMA, 10/23/09

Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial
Osteoporosis International, 10/06/09

See All of Bone Metabolism