Rheumatology Medical News about vitamin D-binding gene;compression strength index

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Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families
Osteoporosis International, 06/25/09

Xu XH et al. - Findings suggest that the vit D-binding protein (DBP) gene might be one of the genetic factors influencing compression strength index (CSI) phenotype in Caucasians, especially in males.

Methods

Aim was to investigate if an association exists between DBP gene and CSI phenotype
12 SNPs of the DBP gene for association with CSI variation were examined in 405 Caucasian nuclear families comprising 1,873 subjects from the Midwestern US
Association analyses were performed in the total sample, male and female subgroups, respectively

Results

Significant associations with CSI were found with 2 SNPs (rs222029 and rs222020) for the male subgroup
Haplotype-based association tests corroborated the single-SNP results

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