Rheumatology

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Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families
Osteoporosis International, 06/25/09

Xu XH et al. - Findings suggest that the vit D-binding protein (DBP) gene might be one of the genetic factors influencing compression strength index (CSI) phenotype in Caucasians, especially in males.

• Aim was to investigate if an association exists between DBP gene and CSI phenotype
• 12 SNPs of the DBP gene for association with CSI variation were examined in 405 Caucasian nuclear families comprising 1,873 subjects from the Midwestern US
• Association analyses were performed in the total sample, male and female subgroups, respectively

• Significant associations with CSI were found with 2 SNPs (rs222029 and rs222020) for the male subgroup
• Haplotype-based association tests corroborated the single-SNP results

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