Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
Interferon-γ is increased in patients with primary Sjogrens syndrome and Raynauds phenomenon
Seminars in Arthritis and Rheumatism, 06/30/09
Willeke P et al. – Data suggest a pathogenic role of INF-γ in primary Sjogren's syndrome (pSS) patients with Raynaud's phenomenon (RP). Whether the RP is immune-mediated or whether INF-γ directly causes vasospasm still remains to be elucidated.
Methods- Main objectives of this study were to:
- Determine the prevalence of RP in pts with pSS
- Identify clinical and immunological characteristics associated with this manifestation
- Compare the INF-γ production in pSS pts with or w/o RP
- RP was diagnosed if pSS pts presented with characteristic sequence of skin color changes of the digits
- In uncertain cases noninvasive vascular tests were performed by ultrasound
- Secretion of INF-γ by PBMC was assessed by ELISA
- Expression of different lymphocyte activation markers (CD25, CD45RO, CD69) on CD4+ T-cells was examined by flow cytometry
- 36/108 pts with pSS had RP
- These pts had an increased number of INF-γ-secreting peripheral blood mononuclear cells vs pts w/o RP or healthy controls
- Further, in pts with RP an increased percentage of CD25-positive T-helper cells was detectable
- In addition, an association of leukopenia, thyroiditis, and lower C3 levels with RP in pSS pts was seen
Related Articles
Analysis of rewarming curves in Raynaud's phenomenon of various aetiologies
Journal of Hand Surgery (European Volume), 11/06/09
Relevance Score: 68%
Brachial Artery Fibromuscular Dysplasia
Annals of Vascular Surgery, 11/10/09
Relevance Score: 64%
Systemic Sclerosis: Bilateral Improvement of Raynauds Phenomenon with Unilateral Digital Sympathectomy
Seminars in Arthritis and Rheumatism, 11/10/09
Relevance Score: 64%
Long-term outcome of patients with polymyositis/ dermatomyositis and anti-PM-Scl antibody
British Journal of Dermatology, 10/26/09
Relevance Score: 64%
Prevalence, risk factors, and clinical correlates of ulnar artery occlusion in the general population
Journal of Vascular Surgery, 10/20/09
Relevance Score: 64%
Today in Autoimmune/Heritable...keeping you current
Receive free subspecialty "5-minute updates" via email
Genetic background of systemic sclerosis: autoimmune genes take centre stage
Rheumatology, 11/23/09
Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity
Rheumatology, 11/20/09
T Cell Responses to Steroid Cytochrome P450 21-Hydroxylase in Patients with Autoimmune Primary Adrenal Insufficiency
Journal of Clinical Endocrinology and Metabolism, 11/20/09
Sponsor
Article Search
Sponsor


See Latest Articles


