Rheumatology

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Nerve growth factor in rheumatic diseases
Seminars in Arthritis and Rheumatism, 06/30/09

Seidel MF et al. – Nerve growth factor (NGF), is a significant mediator and modulator of inflammation. NGF may shows detrimental or regenerative activity. These findings indicate potential therapeutic interventions using either NGF antagonists or recombinant NGF.

• Review of the role of NGF in rheumatic diseases and strategies for potential therapeutic interventions
• Database search using Medline and Medpilot
• Assessment of 800 abstracts for keyword NGF and other keywords
• Analysis of articles based on relevance and content
• Inclusion of most clinical trials and studies with human specimens
• Selection of studies with experimental animal models with relevant data

• NGF overexpression in many inflammatory and degenerative rheumatic diseases
• Concentrations differ and may show contradictory results
• NGF in serum, synovial fluid, and cerebrospinal fluid, and tissue specimens
• NGF concentrations correlate with extent of inflammation and/or clinical activity in many conditions
• NGF levels significantly higher in rheumatoid arthritis vs osteoarthritis

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