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See Latest ArticlesHuman osteoarthritic chondrocytes are impaired in matrix metalloproteinase-13 inhibition by IFN-gamma due to reduced IFN-gamma receptor levels
Osteoarthritis and Cartilage , 06/24/09
Ahmad R et al. - Ability of IFN-gamma to suppress IL-1-induced MMP-13 expression is diminished in OA chondrocytes due to decreased IFN-gamma-R1 levels, activity and impaired downstream signal transduction. Therefore, IFN-gamma-R1 modulation and weakened endogenous IFN-gamma response may be important mechanisms in OA pathogenesis and cartilage degradation.
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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
Rheumatology, 12/20/09
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis
Arthritis Research & Therapy, 12/19/09
Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation
Journal of Rheumatology, 12/17/09
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