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See Latest ArticlesHypoxia reduces the inhibitory effect of IL-1-beta on chondrogenic differentiation of FCS-free expanded MSC
Osteoarthritis and Cartilage , 06/26/09
Felka T et al. - Inflammatory processes inhibit the chondrogenic differentiation of MSC. This may lessen the regenerative potential of MSC in situ. Thus, for the cell therapy of IDs using MSC to be effective it will be necessary to manage the inflammatory conditions in situ. In contrast, hypoxic conditions exert beneficial effects on chondrogenesis and phenotype stability of transplanted MSC, and may improve the quality of the generated ECM.
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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
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Arthritis Research & Therapy, 12/19/09
Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation
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