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Mansouri LE et al. - A 72-year-old male with a 4-year history of TNF-alpha antagonist therapy (infliximab and etanercept) for ankylosing spondylitis was diagnosed with breast cancer. He had a family history of breast cancer. The low incidence and considerable severity of breast cancer in males, genetic risk factors, and potential role for TNF-alpha antagonist therapy are discussed.

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