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See Latest ArticlesTreatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials
Pain, 06/23/09
Häuser W et al. - Study concludes that the usage of gabapentin (GPT) and pregabalin (PGB) can be considered for the treatment of pain and sleep disturbances in FMS patients. Because of some dose-dependent relevant side effects of both drugs the treatment should start with low dosage and then increased slowly with small dosages.
Methods- Aim of this systematic review and meta-analysis was to determine the clinical relevance of GPT/PGB for the treatment of FMS
- MEDLINE, PsycINFO, SCOPUS, www.clinicaltrials.org, the Cochrane Library (through October 2008), and the reference sections of original studies on GPT/PGB in FMS were searched
- Randomized controlled trials (RCTs) on the treatment of FMS with GPT and PGB were analyzed
- 6/127 RCTs studying 2422 subjects on treatment with GPT (1 study) or PGB (5 studies) and 1056 subjects on placebo with a median treatment duration of 11wks were included
- Strong evidence for a reduction of pain, improved sleep and improved health-related quality of life (HRQOL) but not for depressed mood
- There was strong evidence for a non-substantial reduction of fatigue and of anxiety
- The external validity of the studies was limited because pts with severe somatic and mental disorders were excluded
Today in Chr Fatigue/Fibromyalgia...keeping you current
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What Makes Patients with Fibromyalgia Feel Better? Correlations Between Patient Global Impression of Improvement and Changes in Clinical Symptoms and Function: A Pooled Analysis of 4 Randomized Placebo-controlled Trials of Duloxetine
Journal of Rheumatology, 10/16/09
Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome
Cochrane Reviews, 10/12/09
Fibromyalgia and Myofascial Pain Syndrome - A Dilemma
Indian Journal of Anaesthesia, 10/22/09
Today in Clinical Pharmacology...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
Doxycycline for osteoarthritis of the knee or hip
Cochrane Reviews, 10/23/09
Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09
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