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Inactive disease in polyarticular juvenile idiopathic arthritis: Current patterns and associations
Rheumatology, 06/22/09

Ringold S et al. – Study reports that children with polyarticular juvenile idiopathic arthritis (JIA) spent the majority of their follow-up with active disease; improving outcomes for these subgroups may be an important goal for prospective study.

• Study was undertaken to:
  • Describe the achievement of inactive disease (ID) and remission in JIA and
  • Measure the associations among patient characteristics, imaging results and these outcomes
• Cohort study of children (n=104) with polyarticular JIA diagnosed and treated between Jan 2000 and Dec 2006
• Each pt's disease status (active disease vs ID) was determined for every clinic visit
• Adjusted relative risk estimates were obtained using Mantel–Haenszel methods

• Pts were followed up for an average of 30 mo
• Pts achieved 138 episodes of ID; 51 pts achieved 69 episodes of clinical remission on medication
• When duration of active disease was summed over each pt's f/u, pts spent a mean of 66.3% of their f/u with active disease
• Pts with evidence of joint damage on imaging studies obtained within 6 mo of their first clinic visit spent a mean of 79% of their f/u with active disease
• Pts w/o these findings spent a mean of 58.5% of their f/u with active disease
• Children who were RF+ and children with early evidence of joint damage had higher prevalence of active disease during the f/u

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