Your Article Summary
See Latest ArticlesBiologic therapy in primary systemic vasculitis of the young
Rheumatology, 06/22/09
Eleftheriou D et al. – Data provide evidence of efficacy of biologic agents in children with primary systemic vasculitis (PSV), and highlight the associated infectious complications. Further multicentre standardization of treatment protocols and data collection is required.
Methods- Aim was to describe the biologic treatment regimens and report the efficacy and safety of biologic therapies in children with PSV
- A case series of children with PSV treated with biologic therapy between Feb 2002 and Nov 2007
- Primary outcome assessment measures:
- Daily corticosteroid dose
- Birmingham Vasculitis Activity Score (BVAS), and
- Adverse events (including infection rate)
- 25 pts; median age 8.8 yrs; 11 male with active PSV:
- 6 with anti-neutrophil cytoplasmic antibody associated vasculitides
- 11 with polyarteritis nodosa
- 7 with unclassified vasculitis and
- 1 with Behçet's disease
were treated with biologic agents including infliximab, rituximab, etanercept, adalimumab or multiple biologics sequentially
- A reduction in BVAS from a median of 8.5 at start of therapy to 4 at 32 mo f/u
- This was accompanied by reduction in median daily prednisolone requirement from 1 to 0.25 mg/kg/d
- For those receiving multiple biologic agents sequentially, a similar clinical improvement was observed with corticosteroid sparing
- Infections occurred in 24%, the most severe in those receiving infliximab
Related Articles
Livedoid vasculiltis associated with a double heterozygous Factor V Leiden and prothrombin G20210A gene mutations
Clinical and Experimental Dermatology, 10/08/09
Relevance Score: 92%
Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: Results of the first UKCCSG/SIOP CNS 9204 trial
European Journal of Cancer, 10/13/09
Relevance Score: 90%
Young parents' perceptions of barriers to antenatal and postnatal care
British Journal of Midwifery, 10/06/09
Relevance Score: 90%
Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study
Journal of Clinical Oncology, 10/06/09
Relevance Score: 90%
Insights into the pathogenesis of axial spondyloarthropathy based on gene expression profiles
Arthritis Research & Therapy, 11/13/09
Relevance Score: 89%
Today in Vasculitic Syndromes...keeping you current
Receive free subspecialty "5-minute updates" via email
Wegeners granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography
Modern Rheumatology, 12/20/09
Is bioptic assurance reasonable in patients with Sjogren’s syndrome
Zeitschrift für Rheumatologie, 12/20/09
Bowel perforations in a patient affected by Churg–Strauss syndrome under high-dose steroid treatment: will alternative drugs reduce risk of surgery
Rheumatology International, 12/20/09