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rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
Trends in RA patients' adherence to subcutaneous anti-TNF therapies and costs
Current Medical Research and Opinion, 06/26/09
Borah BJ et al. – Study reports that etanercept (ETA) users had longer treatment duration, were more likely to adhere to their medication regimen and had lower rheumatoid arthritis (RA)-related pharmacy and RA-related total costs compared with adalimumab (ADA) users.
Methods- Main objectives of study were:
- To examine adherence to ADA and ETA and health care costs in RA pts, and
- To explore the association between adherence, utilization and costs
- RA pts treated with etanercept or adalimumab during Jan 2005-Dec 2005 were identified
- Patient adherence and costs were assessed during the 1 yr post-index period (first dispensing date)
- Nonadherence was modeled using logistic regression
- Hazard ratios (HR) comparing time to discontinuation were estimated using Cox proportional hazard (PH) models
- Compared with ADA users, ETA users had longer average treatment duration
- Unadjusted adherence rates for naïve and existing users were 63% and 70% (ADA), and 65% and 73% (ETA)
- Compared with ETA users, ADA users were more likely to be nonadherent
- Existing ADA users were more likely to discontinue their medication than existing ETA users
- Compared with ADA users, ETA users had lower RA-related pharmacy costs and RA-related total costs
Today in Clinical Pharmacology...keeping you current
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Interferon-[alpha] mediates suppression of C-reactive protein: Explanation for muted C-reactive protein response in lupus flares?
Arthritis & Rheumatism, 12/06/09
MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
Arthritis & Rheumatism, 12/06/09
Long-term experience with etanercept in psoriatic arthritis patients: A 3-year observational study
Journal of Dermatological Treatment , 12/04/09
Today in Rheumatoid Arthritis...keeping you current
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Associations between the American College of Rheumatology pediatric response measures and the continuous measures of disease activity used in adult rheumatoid arthritis: A secondary analysis of clinical trial data from children with Polyarticular-Course Juvenile Idiopathic Arthritis
Arthritis & Rheumatism, 12/06/09
MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
Arthritis & Rheumatism, 12/06/09
Bone marrow edema is the most specific finding for rheumatoid arthritis (RA) on noncontrast magnetic resonance imaging of the hands and wrists: A comparison of patients with RA and healthy controls
Journal of Rheumatology, 12/06/09
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