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See Latest ArticlesGeranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Modern Rheumatology, 06/18/09
Nanke Y et al. – Study demonstrates that geranylgeranylacetone (GGA) induces cell death in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), suggesting that GGA may be a potential new therapeutic agent for RA as well as osteoporosis.
Methods- An investigation of whether GGA induces cell death in RA synoviocytes
- Synovial tissues were obtained from pts with RA at the time of total knee arthroplasty
- FLS cultured in 3 passages were used for the experiments
- The FLS were then cultured for 48 h in 48-well flat-bottomed plates containing various concns of GGA (0.1–4.0 µg/ml) and either 0.1 or 0.5 µM Fluv
- Effect of GGA and Fluv in human fibroblasts from normal skin (CCD-25SK) and FLS from pts with osteoarthritis (OA) were also examined
- Cells demonstrating cell death were counted following trypan blue staining
- In the absence of GGA, there was no apparent cell death
- Concns of GGA between 0.1 and 4.0 µg/ml induced cell death in RA FLS, but not in skin fibroblasts (CCD-25SK) nor OA FLS
- Number of synoviocytes demonstrating cell death induced by 0.1 or 0.5 µM Fluv was higher vs medium alone
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