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Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection
Clinical Immunology, 06/18/09

Jones KL et al. – Data suggest that almost all patients with Lyme arthritis have strong IgG antibody responses to Borrelia burgdorferi glycolipid antigens.

Methods

Aim was to assess the immunogenicity of the membrane lipids of B. burgdorferi using serum samples from human pts with early or late manifestations of Lyme disease
Membrane lipids of B. burgdorferi were separated into 16 fractions
Components in each fraction were identified
Immunogenicity of each fraction was determined by ELISA using sera from Lyme disease pts

Results

Only the 2 glycolipids, acylated cholesteryl galactoside (ACG, BbGL-I) and monogalactosyl diacylglycerol (MgalD, BbGL-II), were immunogenic
Early in the infection, 29% of pts who were convalescent from erythema migrans and 19/35 pts (54%) with neuroborreliosis had weak IgG responses to purified MgalD
A smaller percentage of pts had early responses to synthetic ACG
However, almost all of 75 pts with Lyme arthritis, a late disease manifestation, had strong IgG reactivity with both glycolipids

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