Rheumatology Medical News about interleukin-8;synovial fluid neutrophil expression;rheumatoid arthritis

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Synovial fluid neutrophil expression of interleukin-8 in rheumatoid arthritis
Modern Rheumatology, 06/17/09

Kasama T et al. – Data suggest that synovial fluid (SF) neutrophil-associated IL-8 and the activated state of SF neutrophils may be considered as an indicator for local and also systemic inflammation of rheumatoid arthritis (RA); this C-X-C chemokine may contribute to the recruitment of neutrophils from the bloodstream into synovial joints.

Methods

Aim was to investigated the contribution of SF neutrophils to augmented concns of IL-8, seen in RA SF

Results

Neutrophils in RA SF contained large amounts of IL-8 protein and its transcript vs either peripheral blood neutrophils of RA pts or of normal individuals
Amount of SF neutrophil-associated IL-8 correlated with the disease activity of RA
In addition, membrane expression of TNF receptor (type I and II) or superoxide generation was increased in RA SF neutrophils

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