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Association of the HLA-DR4 gene complex with auto-antibodies in rheumatoid arthritis patients
Modern Rheumatology, 06/18/09

Xinping T et al. - Although DR4 is an important indicator for severe rheumatoid arthritis (RA) and poor prognosis, it is only associated with rheumatoid factor (RF). Moreover, no correlation could be found between these auto-antibodies.

• Aim was to investigate in RA pts (n=45) the correlation of HLA-DR4 gene complex with:
  • Rheumatoid factor (RF)
  • Anti-RA33/36 antibody
  • Anti-keratin antibody (AKA) and
  • Anti-perinuclear factor (APF)
• PCR-SSP method was used to examine the DR4 gene complex
• Anti-RA33/36 Ab and RF were tested by Western blot and latex agglutination test respectively
• AKA and APF were tested by the indirect immunofluorescence method

• DR4 gene complex was present in 60% pts; RF positivity was 68.9%
• DR4(+) pts had a higher RF positive rate (66.7%) than DR4(-) pts (33.3%)
• Anti-RA33/36 Ab was positive in 37.8% pts; was present in 33.3% DR4(+) pts and in 38.9% DR4(-) pts; no difference
• AKA (1:80) was positive in 28.9% pts; was present in 33.3% DR4(+) pts and in 22.2% DR4(-) pts; no significant difference
• APF could be detected in 53.3% of pts; was positive in 51.9% DR4(+) pts and 55.5% DR4(-) pts; no significant difference
• In addition, no association could be found between RF, anti-RA33/36 antibody, AKA and APF

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