Rheumatology Medical News about bone turnover;endogenous Cushings syndrome

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Bone turnover in patients with endogenous Cushings syndrome before and after successful treatment
Osteoporosis International, 06/17/09

Szappanos A et al. - Study demonstrates a correlations between serum cortisol and both bone formation and resorption markers in the active phase of Cushing’s syndrome (CS); osteocalcin (OC) may serve as a sensitive biologic marker of glucocorticoid activity in endogenous CS during its active phase and may reflect the clinical cure of the disease.

Methods

An investigation of:
- Time course of bone marker changes after the cure of CS, and
- Correlations between bone markers and serum cortisol concns
87 pts; followed up to 48 mo after surgical cure
Serum OC and collagen breakdown products (CTX) in pts were compared with that of 161 healthy controls

Results

OC showed a negative, while CTX displayed a positive correlation with serum cortisol
Pts with diabetes mellitus and myopathy had lower serum OC leve
Postoperative OC increased rapidly from the first few days or wks reaching its max at the sixth mo
It remained stable after the 24th postoperative mo

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