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Crohn’s disease during etanercept therapy in juvenile idiopathic arthritis: a case report and review of the literature
Rheumatology International, 06/18/09

Wiegering V et al. - The authors report on an 11-year-old girl with juvenile idiopathic arthritis, who developed Crohn’s disease (CD) while taking etanercept for her arthritis. Etanercept was discontinued and an antibody-based anti-TNF treatment using adalimumab was started, which induced remission of the gastrointestinal symptoms promptly. This case indicates that immunodysregulatory and even proinflammatory effects of etanercept are of relevance in the clinical practice.

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