Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
See Latest ArticlesIdentification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
Human Molecular Genetics, 06/15/09
Barton A et al. – Study reports a novel association of AFF3 with rheumatoid arthritis (RA) susceptibility; also confirms the association of RA with 2 other loci (CTLA4 and IL2-21/4q27). A total of 13 loci have now been confirmed as associated with RA susceptibility, firmly establishing the concept of common susceptibility loci for autoimmunity.
Methods- Aim was to determine if type 1 diabetes (T1D) susceptibility genes/loci are also associated with RA
- Combined sample cohort of 6,819 RA cases and 12,650 controls
- A novel RA susceptibility locus at AFF3 was identified with convincing evidence for association
- Association of 2 previously described loci (CTLA-4 and 4q27) with RA was also replicated
- These findings take the number of established RA susceptibility loci to 13
- Out of these only one has not been associated with other autoimmune diseases (TRAF1/C5)
Related Articles
Efficacy of roxithromycin in adult patients with rheumatoid arthritis who had not received disease-modifying antirheumatic drugs: A 3-month, randomized, double-blind, placebo-controlled trial
Clinical Therapeutics, 10/15/09
Relevance Score: 71%
Certolizumab Pegol: In Rheumatoid Arthritis
BioDrugs, 11/11/09
Relevance Score: 70%
Assistive technology for rheumatoid arthritis
Cochrane Reviews, 10/09/09
Relevance Score: 70%
Treatment of early RA with infliximab is beneficial
American Pharmacists Association, 11/06/09
Relevance Score: 69%
Abatacept for rheumatoid arthritis
Cochrane Reviews, 10/09/09
Relevance Score: 69%
Today in Autoimmune/Heritable...keeping you current
Receive free subspecialty "5-minute updates" via email
Echocardiography as an Outcome Measure in Scleroderma-related Pulmonary Arterial Hypertension: Results of a Systematic Literature Analysis by the EPOSS Group
Journal of Rheumatology, 12/08/09
Depletion of functionally active CD20+ T cells by rituximab treatment
Arthritis & Rheumatism, 12/07/09
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Effect of Glucocorticoid-, Parathyroid- and Thyroid Hormones Excess on Human Iliac Crest Bone Matrix Insulin-like Growth Factor (IGF)-I in Patients with Osteoporosis
Experimental and Clinical Endocrinology & Diabetes, 12/09/09
Benefit-risk assessment of vitamin D supplementation
Osteoporosis International, 12/09/09
Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis
Annals of Rheumatic Diseases, 12/09/09
Today in Rheumatoid Arthritis...keeping you current
Receive free subspecialty "5-minute updates" via email
Atherogenic lipoprotein phenotype and LDL size and subclasses in drug-naïve patients with early rheumatoid arthritis
Atherosclerosis, 12/09/09
Silica exposure among male current smokers is associated with a high risk of developing ACPA positive rheumatoid arthritis
Annals of Rheumatic Diseases, 12/08/09
MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
Arthritis & Rheumatism, 12/07/09
Sponsor
Article Search
Sponsor