Rheumatology Medical News about immunological reconstitution;autologous hematopoietic cell transplantation;systemic sclerosis

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis: Relationship between clinical benefits and intensity of immunosuppression
Journal of Rheumatology, 06/15/09

Bohgaki T et al. – Data suggest that immunosuppression intensity, sufficient to induce transient suppression of thymic function, is attributable to the feasible clinical response in patients with systemic sclerosis (SSc) treated with autologous hematopoietic stem cell transplantation (HSCT).

Methods

An analysis of the relationship between clinical benefits and immunological changes in SSc pts treated with autologous HSCT
10 pts were treated with high-dose cyclophosphamide followed by highly purified CD34+ cells (n=5) or unpurified grafts (n=5)
2 groups of pts were retrospectively constituted based on their clinical response (good and poor)
Clinical findings, immunological reconstitution through autologous HSCT was assessed by FACS analysis, quantification of sjTREC, reflecting the thymic function, and foxp3 mRNA levels

Results

Pts’ clinical and immunological findings were similar between good and poor responders, or CD34-purified and unpurified groups at inclusion
The sjTREC values were suppressed at 3 mo after autologous HSCT in good responders vs poor responders
Reconstitution of CD4+CD45RO- naive T cells was delayed in good responders vs poor responders
The phenotype of other lymphocytes, cytokine production in T cells, and foxp3 gene expression levels after HSCT did not correlate with clinical response in good or poor responders
Clinical and immunological findings after autologous HSCT were similar between CD34-purified and unpurified groups

<< Previous
AMA: Better care guidelines would slow health spending

Next >>
Efficacy and safety of infliximab in active SLE: A pilot study

Immunologic Markers as Predictors of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in HIV and Tuberculosis Coinfected Persons in Thailand
AIDS Research and Human Retroviruses, 11/09/09 Relevance Score: 64%

Invasive aspergillosis in patients with acute myeloid leukemia: SEIFEM-2008 registry study
Haematologica, 10/27/09 Relevance Score: 64%

NK Cells, Autoantibodies, and Immunologic Infertility: A Complex Interplay
Clinical Reviews in Allergy and Immunology, 11/18/09 Relevance Score: 43%

Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance
Mycoses, 10/20/09 Relevance Score: 42%

Cell-cell cooperation at the T helper cell/mast cell immunological synapse
Blood, 10/09/09 Relevance Score: 42%