Rheumatology Medical News about HLA-G expression;skin;systemic sclerosis

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HLA-G expression in the skin of patients with systemic sclerosis
Journal of Rheumatology, 06/12/09

Wastowski IJ et al. – HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis, suggesting a modulatory role of HLA-G in systemic sclerosis (SSc), as observed in other skin disorders.

Methods

Aim was to determine:
- HLA-G expression in skin biopsies from pts with SSc and
- Its association with epidemiological, clinical, and laboratory variables and survival
Paraffin-embedded skin biopsies obtained from 21 SSc pts (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls
HLA-G expression was evaluated by IHC

Results

HLA-G molecules were detected in 57% of skin biopsies from pts with SSc vs no expression in controls
In pts, HLA-G molecules were consistently observed within epidermal and some dermal cells
HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers, telangiectasias, and inflammatory polyarthralgia
After a 15-yr f/u, SSc pts who exhibited HLA-G survived longer than pts who did not

Exclusive Author Commentary
Isabela Jubé Wastowski, 06/15/09

The pathogenesis of systemic sclerosis (SSc) is complex and remains incompletely understood.Most current hypotheses of the pathogenesis of SSc focus on the interplay between early immunological events and vascular changes. We proposed to evaluate the HLA-G expression in SSc because this disease presents pathogenic characteristics that could be induced HLA-G expression like the stress condition of hypoxia and cytokines profile; moreover, accumulating evidence demonstrates HLA-G expression in chronic inflammatory cutaneous diseases. Our results suggest that HLAG expression in SSc patients could be associated with a more favorable disease course. Although the beneficial role of HLA-G has been demonstrated in some auto-immune diseases, no previous study had been conducted on the evaluation of HLA-G expression in SSc. We hope to continue this study to better understand the HLA-G participation in SSc pathogênesis.

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