Rheumatology Medical News about systemic sclerosis;self-reported physical health status

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Clinical correlates of self-reported physical health status in systemic sclerosis
Journal of Rheumatology, 06/16/09

Hudson M et al. – Study concludes that the clinical characteristics identified as significant correlates of the self-reported physical health status in systemic sclerosis (SSc) should each be targets of intervention in order to improve the health-related quality of life (HRQOL) of patients with this disease.

Methods

Aim was to identify the clinical characteristics that correlate with the physical health status of pts with SSc, as assessed by SF-36
416 pts, assessed with detailed clinical histories, medical examinations, and self-administered SF-36
Multiple linear regression was used to assess the relationship between selected demographic and clinical variables and the SF-36 Physical Component Summary (PCS) score

Results

Greatest impairments in the SF-36 were in the domains measuring physical health, and the mean SF-36 PCS score was 37.5
Multivariate analysis: significant clinical predictors of the SF-36 PCS were shortness of breath, number of gastrointestinal problems, skin score, swollen joint count, and age
Final model explained 47% of the variance in the SF-36 PCS

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Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
Journal of Rheumatology, 10/15/09 Relevance Score: 72%

Necrotizing fasciitis in a patient with overlap syndrome of systemic sclerosis and systemic lupus erythematosus
Rheumatology International, 11/16/09 Relevance Score: 68%

Aerobic Exercise is Safe and Effective in Systemic Sclerosis
International Journal of Sports Medicine, 10/14/09 Relevance Score: 67%

High frequency ultrasound measurement of digital dermal thickness in systemic sclerosis
Annals of Rheumatic Diseases, 10/23/09 Relevance Score: 66%

Mechanisms of vascular damage in systemic sclerosis
Autoimmunity, 10/02/09 Relevance Score: 66%