Rheumatology Medical News about disease-specific;variables;depression;sleep disturbance;fatigue;ankylosing spondylitis

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Fatigue in patients with ankylosing spondylitis: Relationships with disease-specific variables, depression, and sleep disturbance
Clinical Rheumatology, 06/10/09

Gunaydin R et al. – Study concludes that half of the patients with ankylosing spondylitis (AS) had severe fatigue, and multi-dimensional assessment was provided to understand specific aspects of fatigue better. Besides fatigue, effects of psychogenic factors, especially depression, should be taken into consideration in the management of AS.

Methods

Study was conducted to evaluate:
- Frequency of fatigue and its multi-dimensional nature, and
- Its association with:
  - Demographic variables
  - Disease-specific variables, and
  - Other variables, covering depression and sleep disturbance
    in patients with AS (n=62)
Fatigue was assessed by: fatigue item of BASDAI and MFSI-SF
Disease activity was evaluated by the BASDAI
Functional state was assessed by Bath Ankylosing Spondylitis Functional Index
Metrological measurements by Bath Ankylosing Spondylitis Metrology Index
Global well-being by Bath Ankylosing Spondylitis Global Score
Pain on rest by VAS (0–10 cm)
Sleep disturbance by Pittsburgh Sleep Quality Index, and
Depressive symptoms by Zung Self-Rating Depression Scale

Results

50% of the pts had severe fatigue
Disease-specific variables, covering pain, stiffness, disease activity, and physical functioning, contributed to both BASDAI fatigue and MFSI-SF as dependent variables
Disease activity was the most powerful predictor of both single-dimensioned and multi-dimensioned fatigue
Contribution of depression on fatigue was 12%

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