Rheumatology Medical News about SLE;response to ODN-CpG by B cells;disease activity

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Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity
Lupus, 06/10/09

Zorro S et al. – Findings suggest that the B cell response to CpG oligodeoxynucleotides (ODN-CpG) correlates with the systemic lupus erythematosus (SLE) activity, independently of TLR9 expression, indicating that alterations in B cell response in severe activity SLE may be caused by events down-stream to TLR9.

Methods

An investigation of whether alterations in the phenotype of circulating antigen-presenting cells (APCs) and in the response to ODN-CpG correlate with SLE disease activity
APC expression of HLA-DR, costimulatory molecules, and TLR9 expression was determined in pts with SLE, other autoimmune diseases, and healthy controls
Monocyte and B cell response to synthetic ODN-CpG sequences was also evaluated

Results

Monocytes from pts with moderate SLE activity had higher expression of CD40 and CD86
Decreased numbers of CD19+CD80+ and BDCA-3+CD40+ cells were found in pts with severe SLE activity
In pts with moderate SLE activity, non-adherent and enriched B cell response to ODN-CpG was similar to healthy controls
Adherent and enriched B cells from pts with severe SLE activity did not increase costimulatory molecule expression or cytokine production after ODN-CpG stimulation
APCs from pts with SLE, regardless of disease activity, displayed higher percentage of TLR9+ cells, as well as increased expression of TLR9 vs healthy controls

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