Rheumatology Medical News about systemic lupus erythematosus;anti-cyclic citrullinated peptide antibodies

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

The detecting and clinical value of anti-cyclic citrullinated peptide antibodies in patients with systemic lupus erythematosus
Lupus, 06/10/09

Qing YF et al. – Findings suggest that anti-cyclic citrullinated peptide (anti-CCP) positive systemic lupus erythematosus (SLE) patients were more likely associated with hand poly-arthritis, and high titre of anti-CCP antibodies might be used as a predictor for the complication of erosive arthritis.

Methods

A comparison of the prevalence of anti-CCP Abs in SLE patients with and w/o arthritis and in patients with rheumatoid arthritis (RA)
Anti-CCP Abs were measured using ELISA in:
- 159 SLE pats with arthritis (12 pts with erosive arthritis)
- 108 SLE patients w/o arthritis
- 76 RA patients, and
- 87 healthy subjects (controls)

Results

Following had anti-CCP Abs above the cut-off level (5 U/ml):
- 27.3% of SLE patients
- 42.1% SLE patients with arthritis
- 5.6% SLE patients without arthritis
- 85.5% RA patients and
- 1.1% controls
Mean titre of anti-CCP Abs in the SLE group was much lower vs RA group but higher in SLE pts with erosive arthritis vs non-erosive arthritis
Hand poly-arthritis occurred more frequently in anti-CCP-positive SLE pts with erosive arthritis vs non-erosive arthritis
Anti-CCP Abs were prevalent in some SLE pts, more prevalent in SLE pts with arthritis vs w/o arthritis

<< Previous
Response to ODN-CpG by B Cells from patients with systemic lupus...

Next >>
Very recent onset arthritis: The value of initial rheumatologist...