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Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients
Nephrology Dialysis Transplantation, 06/08/09

Park JT et al. - Study concludes that hyperuricaemia is common among peritoneal dialysis (PD) patients and is significantly associated with the rate of decline of residual renal function (RRF).

• Study was conducted to investigate:
  • the prevalence of hyperuricaemia and
  • the relationship between UA and RRF in PD pts
• 134 PD pts who started dialysis between Jan 2000 and Dec 2005
• Timed urine collections were performed within 1 month of PD commencement and at 6-mo intervals thereafter
• The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient
• Biochemical and clinical data at the time of initial urine collection were considered as baseline

• At baseline, 32.8% of the PD pts had hyperuricaemia; majority of them were diabetic
• Hypertensive pts had a higher UA level vs normotensive pts
• The overall reduction rate of RRF in hyperuricaemic pts was higher vs normouricaemic group
• Hyperuricaemia and history of DM showed a negative correlation with the reduction rate of RRF after adjusting for:
  • demographic data, comorbid conditions,
  • body mass index, baseline RRF and medications

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