Rheumatology Medical News about RA;spondyloarthritis;nerve growth factor;receptor expression

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Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis
Arthritis Research & Therapy, 06/08/09

Barthel C et al. – Study reports that neurotrophins and especially nerve growth factor (NGF) are expressed in the synovial fluid and tissue of patients with peripheral synovitis; warrants further functional investigation of their active involvement in chronic inflammatory arthritis.

Methods

Aim was to investigate the presence of NGF in inflamed synovial compartment
mRNA expression levels of 4 ligand and their receptors were determined in the synovial fluid (SF):
- Ligands: NGF, brain derived growth factor (BDNF), neurotrophin(NT)-3, NT-4
- Receptors: tyrosine kinase(trk)A, trkB, trkC, NGFRp75
Subjects: 9 pts with RA and 16 with spondyloarthritis (SpA) were compared to 7 OA pts
NGF was also determined in synovial tissue (ST) biopsies of 10 RA and 10 SpA pts
Production of NGF by monocytes and lymphocytes was assessed by flow cytometry of SF cells
Synovial tissue derived fibroblast-like synoviocytes (FLS) were assessed by ELISA on culture supernatant

Results

BDNF and NGF mRNA expression was noted in SF cells with higher NGF expression in RA and SpA pts vs OA group
NGF expression was higher in ST samples of RA vs SpA
Presence of NGF protein on both CD3+ T lymphocytes and CD14+ cells monocytes/macrophages was seen in the 2 inflammatory arthritis groups
Whereas cultured FLS did not produce NGF in vitro

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