Rheumatology Medical News about hyperhomocysteinema;raloxifene;bone strength

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia
Osteoporosis International, 06/05/09

Saito M et al. – Data demonstrate that hyperhomocysteinemia reduced bone strength via a reduction of enzymatic cross-links and an increase of nonenzymatic cross-links. Raloxifene (RLX) may ameliorate hyperhomocysteinemia-induced detrimental cross-linking in rabbits with ovariectomy (OVX) and may improve bone strength via the amelioration of collagen cross-links.

Methods

An investigation of whether RLX ameliorated hyperhomocysteinemia-induced cross-link abnormalities using a Met-rich diet rabbit model
White rabbits were divided into 6 groups:
- baseline control
- sham operation
- sham + 1% Met diet (OVX)
- 1% Met diet + OVX
- OVX+RLX (10 mg/kg/d), and
- 1% Met diet + OVX + RLX
RLX was administered for 16 wks
Amount of enzymatic immature and mature pyridinium cross-links and the nonenzymatic cross-link, Pen, was measured
Cross-link content was correlated to bone strength

Results

Hcys levels were higher in the Met diet groups vs normal diet groups
Met-fed rabbits with or w/o OVX showed a reduction of enzymatic cross-links
Whereas, an increase in Pen was observed in Met-fed rabbits with OVX
Cross-link content of the RLX-treated Met-fed rabbits with OVX was restored to similar levels as the sham group, accompanied by an improvement of bone strength