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Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus
Arthritis Care and Research , 06/02/09

Several mood and anxiety disorders were more common in women with SLE compared with the general population, and disease activity may contribute to this higher risk. Brief self-report questionnaires may help providers identify patients with these conditions, particularly when patients are reluctant to disclose their symptoms.

Methods

Three hundred twenty-six white women with SLE completed the Composite International Diagnostic Interview and the Systemic Lupus Activity Questionnaire, a self-report measure of SLE disease activity
The binomial test was used to compare the prevalence of psychiatric diagnoses in patients with SLE with a population sample of white women.

Results

Sixty-five percent of the participants received a lifetime mood or anxiety diagnosis.
MDD (47%), specific phobia (24%), panic disorder (16%), obsessive-compulsive disorder (9%), and bipolar I disorder (6%) were more common among patients with SLE than among other white women (P = 0.00009 for specific phobia; for all other values P = 0.00001).
Although most patients with histories of mood disorders reported their psychiatric symptoms to a medical provider, a substantial number of patients with anxiety disorders did not.