Rheumatology Medical News about juvenile dermatomyositis;calcinosis

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis
Arthritis & Rheumatism, 06/04/09

Gunawardena H et al. – Study demonstrates that anti-p140 autoantibodies represent a major autoantibody subset in juvenile dermatomyositis (DM). This specificity may identify a further immunogenetic and clinical phenotype within the juvenile myositis spectrum that includes an association with calcinosis.

Methods

Aim was to describe autoantibodies to a 140-kd protein in children with Juvenile DM
Clinical data and sera were collected; sera that recognized a 140-kd protein by IP were identified
Identity of the p140 autoantigen was investigated by IP/immunodepletion, using Abs to NXP-2, reference anti-p140, and anti-p155/140, the other autoantibody recently described in juvenile DM
DNA samples from 100 Caucasian children with myositis were genotyped for HLA class II haplotype associations and compared with 864 control subjects

Results

Sera from 37/162 (23%) pts with juvenile myositis were positive for anti-p140 autoantibodies
These were detected exclusively in pts with juvenile DM vs juvenile DM-overlap syndrome or control subjects
No anti-p140 antibody-positive pts were positive for other recognized autoantibodies
Immunodepletion suggested that the identity of p140 was consistent with NXP-2
In children with anti-p140 Abs, the association with calcinosis was compared with the rest of the cohort
The clinical features of pts with anti-p140 autoantibodies were different from those of children with anti-p155/140 autoantibodies
Presence of HLA-DRB1*08 was a possible risk factor for anti-p140 autoantibody positivity

<< Previous
Improved endothelial function after endothelin receptor blockade...

Next >>
Elevated serum interferon-α activity in juvenile...