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See Latest ArticlesDifferential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis
Rheumatology, 06/01/09
van den Ham HJ et al. - Cluster analysis identified cytokines in plasma and synovial fluid (SF) samples that were quite different, which underscore the differential cytokine signalling in these two compartments, and suggest that plasma samples may not be suitable for estimating joint biomarker profiles and inflammation.
Methods- Aim was to visualize the pattern of juvenile idiopathic arthritis (JIA), using cluster analysis
- Cytokine measurements were performed using multiplex immunoassays
- Pattern of 30 cytokines in plasma and SF of JIA, RA, OA, or diabetes type II pts and healthy controls were compared
- Oligo- and polyarticular JIA have similar biomarker profiles, both in plasma and SF
-
- Systemic onset JIA (SoJIA) has a profile distinct from other JIA subtypes-
- suggesting that they involve different inflammatory processes
- SoJIA samples do, however, cluster together with RA in SF-
- suggesting that these two conditions have similar cytokine profiles
- Furthermore several clusters of ILs and chemokines were identified that are co-expressed-
- suggesting that they are co-regulated
- Systemic onset JIA (SoJIA) has a profile distinct from other JIA subtypes-
-
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