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See Latest ArticlesIntima–media thickening in patients with familial Mediterranean fever
Rheumatology, 06/01/09
Ugurlu S et al. – Study reports that the increased atherosclerosis defined as the presence of plaques was not observed in patients with familial Mediterranean fever (FMF). The significance of increased C- and F-IMT among patients with FMF must be further assessed.
Methods- Aim was to assess the frequency of atherosclerotic plaques and intima–media thickness (IMT) in pts with FMF vs controls
- 100 pts (46 males; mean age: 40 ± 6 yrs); 94 (15 males; mean age: 41 ± 7 yrs) pts with SLE and 103 (44 males; mean age: 40 ± 5 yrs) apparently healthy volunteers as control groups
- Subclinical atherosclerosis was assessed by investigating atherosclerotic plaques and measuring IMT from carotid and common femoral arteries using B-mode ultrasonography (USG)
- Traditional atherosclerotic risk factors were also assessed
- Both FMF and SLE pats had higher carotid (C-IMT) and femoral artery IMT (F-IMT) vs controls
- This was also true after adjustment for atherosclerotic risk factors
- Only pts with SLE had higher frequency of atherosclerotic plaques in the carotid and in the carotid and/or femoral artery
- When all atherosclerotic risk factors were adjusted, again only pts with SLE had risk for atherosclerotic plaques
- In FMF, whereas the presence of atherosclerotic plaques was only associated with diabetes mellitus
- C-IMT was correlated with age, BMI and fasting glucose; and F-IMT with age and BMI
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