Rheumatology

Your Article Summary

See Latest Articles

Intima–media thickening in patients with familial Mediterranean fever
Rheumatology, 06/01/09

Ugurlu S et al. – Study reports that the increased atherosclerosis defined as the presence of plaques was not observed in patients with familial Mediterranean fever (FMF). The significance of increased C- and F-IMT among patients with FMF must be further assessed.

• Aim was to assess the frequency of atherosclerotic plaques and intima–media thickness (IMT) in pts with FMF vs controls
• 100 pts (46 males; mean age: 40 ± 6 yrs); 94 (15 males; mean age: 41 ± 7 yrs) pts with SLE and 103 (44 males; mean age: 40 ± 5 yrs) apparently healthy volunteers as control groups
• Subclinical atherosclerosis was assessed by investigating atherosclerotic plaques and measuring IMT from carotid and common femoral arteries using B-mode ultrasonography (USG)
• Traditional atherosclerotic risk factors were also assessed

• Both FMF and SLE pats had higher carotid (C-IMT) and femoral artery IMT (F-IMT) vs controls
• This was also true after adjustment for atherosclerotic risk factors
• Only pts with SLE had higher frequency of atherosclerotic plaques in the carotid and in the carotid and/or femoral artery
• When all atherosclerotic risk factors were adjusted, again only pts with SLE had risk for atherosclerotic plaques
• In FMF, whereas the presence of atherosclerotic plaques was only associated with diabetes mellitus
• C-IMT was correlated with age, BMI and fasting glucose; and F-IMT with age and BMI

Related Articles

See all related articles

MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09    Relevance Score: 67%

Heart rate variability in familial Mediterranean fever
Rheumatology International, 11/06/09    Relevance Score: 64%

Familial Mediterranean fever gene mutations in the inner northern region of Turkey and genotype-phenotype correlation in children
Journal of Paediatrics and Child Health, 10/27/09    Relevance Score: 64%

Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcets disease
Clinical Rheumatology, 10/06/09    Relevance Score: 64%

Neutrophil-derived S100A12 as novel biomarker of inflammation in Familial Mediterranean Fever
Annals of Rheumatic Diseases, 10/01/09    Relevance Score: 64%

Today in Autoimmune/Heritable...keeping you current

Receive free subspecialty "5-minute updates" via email

Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: A meta-analysis of randomized controlled trials and meta-regression
Rheumatology, 12/08/09

Echocardiography as an Outcome Measure in Scleroderma-related Pulmonary Arterial Hypertension: Results of a Systematic Literature Analysis by the EPOSS Group
Journal of Rheumatology, 12/08/09

Comparison of autoinflammation and autoimmunity using TRAPS and rheumatoid arthritis as prototypes of these conditions
International Journal of Clinical Rheumatology, 12/04/09

 See all of Autoimmune/Heritable

Today in Basic Science/Genetics...keeping you current

Receive free subspecialty "5-minute updates" via email

Effect of Glucocorticoid-, Parathyroid- and Thyroid Hormones Excess on Human Iliac Crest Bone Matrix Insulin-like Growth Factor (IGF)-I in Patients with Osteoporosis
Experimental and Clinical Endocrinology & Diabetes, 12/09/09

Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis
Annals of Rheumatic Diseases, 12/09/09

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash, and immunologic manifestations in lupus patients with European ancestry
Annals of Rheumatic Diseases, 12/09/09

 See all of Basic Science/Genetics