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Prospective evaluation of serum biomarker levels and cartilage repair by autologous chondrocyte transplantation and subchondral drilling in a canine model
Arthritis Research & Therapy, 06/01/09

Nganvongpanit K et al. – Study demonstrates that autologous chondrocyte transplantation (AC) treatment provides superior results to subchondral drilling (SD) treatment, according to morphology, histology, and cartilage marker levels. Furthermore, serum WF6 was found to be a sensitive marker for the non-invasive therapeutic evaluation of cartilage repair procedures.

• An evaluation of:
  • serum chondroitin sulfate (CS) and hyaluronic acid (HA) levels, and
  • capability of cartilage repair of full-thickness cartilage defects
    after treatment with 2 different fundamental surgical techniques: AC and SD
• A 4-mm-diameter full-thickness cartilage defect was created in each of 10 skeletally mature, male outbred dogs
• Dogs were then randomly separated into two groups:
  • Groups A: treated with AC
  • Group B: treated with SD
• An evaluation was made at the 24th week of the experiment
• Serum was analyzed prospectively, preoperatively, and at 6-wk intervals for CS and HA levels by ELISA and ELISA-based assays, respectively

• Cartilage repair assessment score of group A (9.5) was higher than that of group B (2.5)
• Group A also demonstrated a better quality of hyaline-like cartilage repair
• Prospective analysis of serum WF6 and HA levels between the 2 groups did not show any difference
• Serum WF6 levels at the 24th wk of the experiment had a negative correlation with the cartilage repair assessment score
• Serum HA levels tended to positively correlate

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