Rheumatology Medical News about short-term efficacy of NSAIDS;ankylosing spondylitis

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Evaluation of the short-term efficacy of NSAIDs on patients with active ankylosing spondylitis in daily practice: A 3-month, longitudinal, observational study
Rheumatology International, 05/29/09

Cinar M et al. – Data suggest that due to the markedly lower rate of response to the NSAIDs in pts with active ankylosing spondylitis (AS), early identification of those pts who do not respond to NSAIDs and subsequent decision regarding the institution of second-line treatments (anti-TNF) may be of great value in the prevention of irreversible changes that might develop in most of the patients.

Methods

Study to investigate the response rate to NSAIDs and the clinical parameters that might predict the response in pts with active AS
3-month study; 95 consecutive pts; full dose NSAIDs (indometacin 150 mg/d or acemethazine 180 mg/d) were given to pts
Relevant clinical data of all pts’ were recorded at the beginning and on 3 consecutive monthly visits
At the end of the study period, pts who respond to NSAIDs were determined
Demographic, clinical, and laboratory parameters that might influence the response to the NSAIDs were investigated

Results

Response rate to full-dose NSAIDs according to the ASAS20 in pts with active AS was 29.5%
20.0% of the pts were responders according to the ASAS40 criteria
5.6% of the pts responded according to the 5-out-of-6 criteria at wk 12
Pts who responded to the treatment were younger at the study entry and had shorter disease duration

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