Rheumatology Medical News about high-resolution peripheral CT;trabecular and cortical architecture

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Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy
Osteoporosis International, 05/29/09

Cohen A et al. – Study demonstrates that the associations between peripheral high-resolution quantitative computed tomography (HR-pQCT) and axial (transiliac biopsy) measures of microarchitecture and estimated mechanical competence are significant but modest.

Methods

Aim was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the “gold standard,” transiliac bone biopsy
HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects
Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (µCT)
Apparent Young’s modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (µFE) of biopsy µCT and HR-pQCT images

Results

Strongest correlations observed were between trabecular parameters: bone volume fraction, number, separation; measured by µCT of biopsies and HR-pQCT of the radius
Cortical width of biopsies correlated with cortical thickness by HR-pQCT, but only at the tibia
Apparent Young’s modulus calculated by µFE of biopsies correlated with that calculated for both radius and tibia HR-pQCT scans

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