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See Latest ArticlesDifferent properties of antibodies to citrullinated proteins/peptides and IgM rheumatoid factor derived from a large dataset: Further evidence of two distinct autoantibody systems
Arthritis Research & Therapy, 05/26/09
Ursum J et al. – Study reports that antibodies to citrullinated proteins/peptides (ACPA) status is more stable in time and with increasing age than IgM-rheumtoid factor (IgM-RF) status, further establishing its role as a disease specific marker. ACPA and IgM-RF levels are only moderately correlated with markers of inflammation.
Methods- Aim was to examine seroconversion and the relationship with age and inflammation of autoantibodies
- ACPA and IgM-RF levels were determined in 22,427 samples collected from 18,658 pts
- Diagnosis was derived from the diagnosis registration system
- Degree of seroconversion in repeated samples and the correlation of levels with age and inflammatory markers was determined for ACPA and IgM-RF in RA and non-RA pts
- 71% of RA pts were ACPA positive and 53% IgM-RF positivevs 2% and 4%, respectively in non-RA pts
- In pts with at least 2 samples, ACPA status was more stable than IgM-RF status in RA pts
- ACPA or IgM-RF negative non-RA pts seldom became positive
- ACPA positivity was unrelated to age both in RA and non-RA
- IgM-RF positivity was unrelated to age in RA, however, it increased with age in non-RA pts
- Correlation between autoantibody levels and inflammatory markers was low in general, and somewhat higher for IgM-RF than for ACPA
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