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Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses
Journal of Internal Medicine, 06/01/09

Jammes Y et al. – Study reports that the response of chronic fatigue syndrome (CFS) patients to incremental exercise associates a lengthened and accentuated oxidative stress, which might result from delayed and insufficient heat shock proteins (Hsp) production.

Methods

Aim was to test the hypothesis that Hsp expression might be reduced in pts suffering from CFS who present an accentuated exercise-induced oxidative stress
9 CFS pts matched to a gender-, age- and weight- control group of 9 healthy sedentary subjects
All subjects performed an incremental cycling exercise continued until exhaustion
Ventilation and respiratory gas exchange were measured; evoked compound muscle potential (M-wave) recorded from vastus lateralis
Markers of oxidative stress:
- thiobarbituric acid reactive substances (TBARS) and reduced ascorbic acid (RAA)
- 2 cytokines (IL-6 and TNF-α) and two Hsp (Hsp27 and Hsp70)
  measured at rest, during maximal exercise and 60-min recovery period

Results

Resting CFS pts had low baseline levels of RAA and Hsp70 vs controls
Their response to maximal exercise associated:
1. M-wave alterations indicating reduced muscle membrane excitability
2. Early and accentuated TBARS increase accompanying reduced changes in RAA level
3. Absence of significant increase in IL-6 and TNF-?, and
4. Delayed and marked reduction of Hsp27 and Hsp70 variations
Post-exercise increase in TBARS was accentuated in individuals having the lowest variations of Hsp27 and Hsp70

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