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The 30-kDa band from Salmonella typhimurium: IgM, IgA and IgG antibody response in patients with ankylosing spondylitis
Rheumatology, 05/21/09

Zambrano-Zaragoza JF et al. – Study demonstrates an association between the p30 of Salmonella typhimurium and ankylosing spondylitis (AS).

• Aim was to determine the association of S. typhimurium antigens with AS by analyzing:
  • IgA, IgG and IgM antibody response to the crude lysate and
  • 30-kDa band from this micro-organism
• Sera from 28 AS pts, 28 HLA-B27+ healthy relatives, 28 unrelated healthy subjects and 14 RA pts were included
• S. typhimurium proteins were electrophoretically separated and blotted onto nitrocellulose sheets for immunodetection with sera of pts and controls
• Electroeluted 30-kDa band (p30) and a crude lysat (StCL) from S. typhimurium were used as antigen to evaluate the IgM, IgA and IgG Ab levels by ELISA
• An inhibition assay was carried out to confirm the specificity of IgG response to the p30

• 20/28 (71.4%) AS pts and 14.3% unrelated healthy subjects recognized a 30-kDa band from S. typhimurium with IgG Abs
• 21.4% AS pts and 14.3% unrelated healthy subjects detected it with IgA Abs
• Recognition of p30 and StCL by both IgA and IgG Abs was higher in AS pts vs control groups
• Sera from AS pts had higher percentage of IgG Abs p30
• IgG3 subclass was higher in AS pts than in control groups
• No differences in the IgM response were found

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