Rheumatology

Your Article Summary

See Latest Articles

Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
Scandinavian Journal of Rheumatology , 05/20/09

Lei W et al. – Study concludes that reduced DNA methylation and abnormal expression of methylation-related genes in CD4+ T cells are associated with systemic erythematosus lupus (SLE) and systemic sclerosis (SSc).

• Aim was to investigate whether the impaired T-cell DNA methylation occurs in SSc and dermatomyositis (DM) besides SLE
• Global methylation in CD4+ T cells was quantified from:
  • 12 healthy donors and
  • pts with SLE, SSc, and DM (10 pts in each group)
• mRNA levels of DNA methyltransferases (DNMTs) and methyl-CpG-binding domain proteins (MBDs) were measured by RT-PCR

• CD4+ T-cell DNA from pts with SLE (both active and inactive) and SSc, but not DM, was hypomethylated vs controls
• In SLE group, the average expression levels of:
  • DNMT1 and MBD4 mRNA were lower
  • MBD2 and MeCP2 mRNA levels were higher
• In SSc group levels of DNMT1, MBD3, and MBD4 mRNA were decreased
• In DM group, expression levels of MBD2 and MeCP2 mRNA was higher
• Degree of global DNA hypomethylation correlated positively with the relative level of DNMT1 across SLE samples and MBD4 across the SSc samples

Related Articles

See all related articles

Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis
Journal of Rheumatology, 11/06/09    Relevance Score: 94%

Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
Annals of Rheumatic Diseases, 11/23/09    Relevance Score: 92%

The relationship between race, cigarette smoking and carotid intimal medial thickness in systemic lupus erythematosus
Lupus, 11/30/09    Relevance Score: 91%

Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in SLE patients
Clinical Rheumatology, 11/17/09    Relevance Score: 90%

B lymphocyte stimulator expression in pediatric systemic lupus erythematosus and juvenile idiopathic arthritis patients
Arthritis & Rheumatism, 11/04/09    Relevance Score: 90%

Today in Basic Science/Genetics...keeping you current

Receive free subspecialty "5-minute updates" via email

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
Rheumatology, 12/20/09

The 'RASor's' edge: Ras proteins and matrix destruction in arthritis
Arthritis Research & Therapy, 12/19/09

Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation
Journal of Rheumatology, 12/17/09

 See all of Basic Science/Genetics

Today in Connective Tissue Dz...keeping you current

Receive free subspecialty "5-minute updates" via email

Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil
Rheumatology, 12/18/09

Rheumatic heart disease and its control in the Pacific
Expert Review of Cardiovascular Therapy , 12/15/09

Heart rate turbulence assessment in systemic sclerosis: The role for the detection of cardiac autonomic nervous system dysfunction
Rheumatology, 12/11/09

 See all of Connective Tissue Dz

Today in Systemic Lupus (SLE)...keeping you current

Receive free subspecialty "5-minute updates" via email

Increased level of tumor necrosis factor-alpha in patients with antiphospholipid syndrome: marker not only of inflammation but also of the prothrombotic state
Rheumatology International, 12/20/09

Osteonecrosis secondary to antiphospholipid syndrome: a case report, review of the literature, and treatment strategy
Rheumatology International, 12/20/09

A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population
Rheumatology International, 12/19/09

 See all of Systemic Lupus (SLE)