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See Latest ArticlesAntiphospholipid antibodies and kidney involvement in patients with systemic sclerosis
Clinical Rheumatology, 05/19/09
Wielosz E et al. – Study suggests the relationship between kidney involvement and the positivity for some antiphospholipid (aPL) in patients with SSc. Positivity for IgG aCL and IgG a-B2GPI in patients with SSc without secondary antiphospholipid syndrome seems to be connected with decrease of glomerular filtration.
Methods- Aim was to examine the correlation between the presence of aPL and certain markers of renal function in SSc
- 50 pts; examined for presence of Abs to cardiolipin (aCL) and to anti-beta 2 glycoprotein I (a-B2GPI) in immunoglobulin M (IgM) and IgG class
- Serum levels of creatinine, cystatin C, and glomerular filtration rate (GFR) were determined in all pts
- In all studied pts together, 3 multiple-regression analyses were performed:
- with one set cystatin C as a dependent variable
- in the second GFR according to the Cockcroft–Gault formula and
- in the third creatinine clearance by Modification of Diet in Renal Disease (MDRD) formula
- As independent variables, aPL of either type were inserted in addition to disease duration and age
- IgG aCL was positively associated with serum cystatin C, negatively associated with creatinine clearance according to the Cockcroft–Gault and MDRD formula
- IgG a-B2GPI was negatively associated with creatinine clearance according to the Cockcroft–Gault formula
- IgM aCL and IgM a-B2GPI were not associated with any markers of the renal function
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