Rheumatology Medical News about thymus involvement;systemic sclerosis

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Radiological incomplete thymus involution in systemic sclerosis
Rheumatology, 05/21/09

Oksel F et al. – Study shows significantly higher frequency of radiological incomplete thymus involution in SSc compared with normal controls. Furthermore, less common occurrence of pulmonary fibrosis in SSc patients with incomplete thymus involution deserves attention.

Methods

An evaluation of:
- the frequency of radiological thymus abnormalities in SSc pts and
- its relationship with various clinical and laboratory features
63 female SSc pts (diffuse/limited: 49/14), all having pulmonary high-resolution CT (HRCT) scans, taken previously for evaluating lung involvement
Mean age and disease duration of the pts were 50.1 ± 8.5 and 10.2 ± 7.8 yrs, respectively
Control group: 45 age-matched female pts, having normal pulmonary HRCT scans taken previously for evaluating non-specific symptoms

Results

Frequency of incomplete thymus involution was higher in SSc pts vs control group
In SSc pts with pulmonary fibrosis, incomplete thymus involution was lower than those w/o pulmonary fibrosis

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