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See Latest ArticlesAllopurinol and mortality in hyperuricaemic patients
Rheumatology, 05/19/09
Luk AJ et al. – Findings indicate that allopurinol (the most commonly used urate-lowering drug) treatment may provide a survival benefit among patients with hyperuricaemia.
Methods- Aim was to examine the impact of allopurinol on the risk of mortality in hyperuricaemic pts
- A population of hyperuricaemic veterans; ≥40 yrs
- Risk of death between incident allopurinol users (n=2483) and non-users (n=7441) was compared
- Multivariate mortality hazard ratio (HR) of allopurinol use with Cox proportional hazards models
- 9924 veterans (98% male, and mean age 62.7 yrs), 1021 died during the f/u
- Pts who began treatment with allopurinol had worse prognostic factors for mortality, including higher BMI and comorbidities
- After adjusting for baseline urate levels, allopurinol treatment was associated with a lower risk of all-cause mortality
- Further adjustment with other prognostic factors did not appreciably alter this estimate
- Mean change from baseline in serum urate within the allopurinol group was –111 µmol/l
- Adjusting for baseline urate level, allopurinol users had a 40 µmol/l lower f/u serum urate value than controls
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