Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
Allopurinol and mortality in hyperuricaemic patients
Rheumatology, 05/19/09
Luk AJ et al. – Findings indicate that allopurinol (the most commonly used urate-lowering drug) treatment may provide a survival benefit among patients with hyperuricaemia.
Methods- Aim was to examine the impact of allopurinol on the risk of mortality in hyperuricaemic pts
- A population of hyperuricaemic veterans; ≥40 yrs
- Risk of death between incident allopurinol users (n=2483) and non-users (n=7441) was compared
- Multivariate mortality hazard ratio (HR) of allopurinol use with Cox proportional hazards models
- 9924 veterans (98% male, and mean age 62.7 yrs), 1021 died during the f/u
- Pts who began treatment with allopurinol had worse prognostic factors for mortality, including higher BMI and comorbidities
- After adjusting for baseline urate levels, allopurinol treatment was associated with a lower risk of all-cause mortality
- Further adjustment with other prognostic factors did not appreciably alter this estimate
- Mean change from baseline in serum urate within the allopurinol group was –111 µmol/l
- Adjusting for baseline urate level, allopurinol users had a 40 µmol/l lower f/u serum urate value than controls
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09
Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid
Osteoporosis International, 11/25/09
Today in Gout and Hyperuricemia...keeping you current
Receive free subspecialty "5-minute updates" via email
A survey on the management of gout in Malaysia
International Journal of Rheumatic Diseases, 11/25/09
Prescription and comorbidity screening following consultation for acute gout in primary care
Rheumatology, 11/23/09
Osteoclasts are important for bone angiogenesis
Blood, 11/19/09
Sponsor
Article Search
Sponsor


See Latest Articles


