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Serum amyloid A protein stimulates CCL20 production in rheumatoid synoviocytes
Rheumatology, 05/21/09

Migita K et al. – These findings suggest that serum amyloid A (SAA) may be implicated in the recruitment of lymphocytes, including CCR6-expressing Th17 cells, in RA synovium by up-regulating CCL20 production in synoviocytes.

• Aim was to investigate the contribution of SAA to the recruitment of Th17 cells
• Effects of SAA on CCL20 production by RA synoviotytes were studied
• Synoviocytes isolated from RA pts were stimulated with recombinant SAA
• Cellular supernatants were analysed by CCL20-specific ELISA
• CCL-20 mRNA expression was analysed by RT–PCR

• SAA is a most potent inducer of CCL20 secretion in RA synoviocytes vs other inflammatory cytokines
• SAA stimulation induced CCL20 mRNA expression in RA synoviocytes, which was not affected by polymyxin B pre-treatment
• SAA-induced CCL20 production was down-regulated by NF-κB inhibition and partially by c-jun N-terminal kinase (JNK) inhibition
• SAA-induced CCL20 production was also suppressed by dexamethasone or FK506.

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