Rheumatology Medical News about systemic sclerosis;proadhesive phenotype;myeloid cell adhesion

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The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1
Rheumatology, 05/15/09

Rabquer BJ et al. – Findings show that junctional adhesion molecule-B (JAM-C) and CD99 are aberrantly expressed in systemic sclerosis (SSc) skin. However, these adhesion molecules do not mediate myeloid cell–SSc skin adhesion. In contrast, a role for ICAM-1 and VCAM-1 in the retention of myeloid cells in SSc skin is demostrated, suggesting that targeting these molecules may be useful SSc therapies.

Methods

Study to examine adhesive interactions in SSc skin
Expression of JAM-B, JAM-C, CD99, ICAM-1 and VCAM-1 in SSc skin was determined by IHC and cell surface ELISA
Myeloid U937 cell–SSc dermal fibroblast adhesion assays or in situ adhesion assays to SSc skin were performed

Results

JAM-C and CD99 expression on endothelial cells (ECs) in SSc skin was decreased vs expression on normal ECs
CD99 was overexpressed on mononuclear cells in SSc skin and on SSc dermal fibroblasts
Neutralizing ICAM-1 inhibited the binding of U937 cells to SSc dermal fibroblasts
In addition, blocking both ICAM-1 and VCAM-1 inhibited U937 cell adhesion to either proximal (less involved) or distal (more involved) SSc skin

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Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
Journal of Rheumatology, 10/15/09 Relevance Score: 72%

Necrotizing fasciitis in a patient with overlap syndrome of systemic sclerosis and systemic lupus erythematosus
Rheumatology International, 11/16/09 Relevance Score: 68%

Aerobic Exercise is Safe and Effective in Systemic Sclerosis
International Journal of Sports Medicine, 10/14/09 Relevance Score: 67%

High frequency ultrasound measurement of digital dermal thickness in systemic sclerosis
Annals of Rheumatic Diseases, 10/23/09 Relevance Score: 66%

Mechanisms of vascular damage in systemic sclerosis
Autoimmunity, 10/02/09 Relevance Score: 66%