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Millward-Sadler SJ et al. - TNFa does not induce MMP expression to the same degree as stimulation by IL1b, but it does act to upregulate IL1b expression as well as TNFa and TNF-R2. The net result of this would be an increased inflammatory environment and accelerated degradation of the matrix. These results support the hypothesis that while TNFa may be an important initiating factor in matrix degeneration, IL1b plays a greater role in established pathological degradation.

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